A top federal health agency is requesting input on a proposal to establish a standardized dose of THC in marijuana products to ensure consistency among studies into the potential therapeutic benefits and risks of cannabis.
In a notice published by the National Institute on Drug Abuse (NIDA) on Monday, the agency said that little is known about the impact of varying THC potency, and creating a standard unit could help resolve that issue. That said, the notice acknowledges that marijuana contains other compounds that could complicate any standardization, in addition to problems arising from differing methods of consumption.
Even so, “such a unit is critical for conducting rigorous cannabis research,” NIDA said.
“Recognizing that a perfect measure may not be attainable at the current time, NIDA still believes that a standard dose would improve measures of outcomes in relation to exposure; and thus, could inform policy and public health strategies around cannabis use,” the notice states, adding that the agency is looking into a five milligram THC dose as the standardized unit.
NIDA Director Nora Volkow discussed the importance of establishing such a unit in commentary published in the journal Addiction last month.
Citing research that calls for a five milligram THC standard, Volkow said she agreed with the study’s conclusion despite complicating factors. Those factors include potential issues related to the effect of having cannabis products with the same THC level but different concentrations of other cannabinoids such as CBD.
Also, varying routes of administration could present problems in ensuring research consistency. It’s unclear how the effects of a five milligram THC unit would differ between marijuana products consumed via smoking, vaping, edibles or topicals.
Published: March 23, 2020
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